Effect of Resistance Exercise and Liposomal Vitamin C on Some Factors of Mitochondrial Dynamics and Biogenesis

Objective: Aging is associated with some changes in the liver function including increased collagen deposition and decreased mitochondrial function. This study aims to evaluate effect of resistance exercise vitamin C intake on expression Peroxisome Proliferator-Activated Receptor-? Coactivator-1? (PGC-1?) Mitofusin 1 (MFn1) genes older rats. Methods: an experimental conducted 25 male Wistar rats aged 24 weeks weighted 280-320 g. They were randomly divided into five groups young control, exercise, C, + control. In supplementation groups, given liposomal (100 mg/kg per body weight) by gavage daily. One-way ANOVA was used examine difference between Tukey’s post hoc test determine location group differences. For all analyses, significance level set at 0.05. Results: significantly reduced PGC-1? MFn1 tissue (P=0.001). group, a significant increase observed compared control (P=0.001), but there no expression. A decrease reported Conclusion: Resistance combined reduces increases